Sensitivity to fat in dyspepsia
This work unlined the importance of fat in generating dyspeptic symptoms by demonstrating how duodenal infusions of fat could sensitise the stomach to distension and to motion sickness. These effects could be treated by drugs that acted on cholecystokinin, opiate and serotonin receptors.
- Khan, M.I., Read, N.W., Grundy, D. (1993) The effect of varying the rate and pattern of gastric distension upon its sensory perception and motor activity. Am. J. Physiology. 264: G824 –G827.
- Barbera, R., Feinle, C., Read, N.W. (1995) Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia. Europ.J.Gastro. Hep. 7 (11):1051-7.
- Feinle, C., Grundy, D., Read, N.W. (1995) Fat increases vection induced nausea independent of any changes in gastric emptying. Physiol Behav. 58(6):1159-65.
- Barbera, R., Feinle, C., Read, N.W. (1995) Nutrient Specific Modulation of Gastric Mechanosensitivity in patients with functional dyspepsia. American Journal of Physiology. Digestive Diseases & Sciences. 40: 1636-1076.
- Feinle, C., D’Amato, M., Read, N.W. (1996) Cholecystokinin-A receptors modulate gastric sensory & motor responses to gastric distention & duodenal lipids. Gastroenterology. 110: 1379-1385.
- Feinle C, Read NW. (1996) Ondansetron reduces nausea induced by gastro duodenal stimulation without changing gastric motility. Am. J. Physiol. 271: G59l – 597
- Read N.W., Freitag B, Abitbol JL. (l997) Efficacy and safety of the peripheral kappa agonist, fedotozine, versus placebo in the treatment of functional dyspepsia. Gut 4l: 664 – 668
- Read N.W. (1999). Functional Dyspepsia: a case of indecision. Gastroenterology (editorial). 116 (3):515 – 520.
